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Updated: Oct 18, 2025
Author Spotlight: Integrating Eastern and Western Medicine for Treatment of Granulomatous Mastitis
Published on: May 3, 2024
Low-Dose Methotrexate Use in Idiopathic Granulomatous Mastitis: An Alternative Treatment Method
Mehmet Tolga Kafadar1, Mehmet Veysi Bahadır1, Sadullah Girgin1
1Department of General Surgery, Dicle University School of Medicine, Diyarbakır, Turkey.
Background:
Idiopathic granulomatous mastitis (IGM) is a rare, recurrent and progressive breast disease with an unknown etiology. Patients with IGM will probably face stressful, time-consuming treatment procedures with side effects due to medications. There are different treatment modalities in clinical use including medical and surgical interventions.
Objective:
The aim of this study was to present the results of using the combination therapy of low-dose methotrexate (MTX) and steroid in IGM.
Methods:
Seventeen patients diagnosed with IGM and treated with MTX were included into the study. Low-dose MTX at 5 mg/week and 8 mg/day prednisone were given for 2-3 months.
Results:
After 2-3 months of treatment, 10 patients exhibited (58.5%) complete, 3 patients (17.6%) partial recovery, and no response to the treatment process was observed in 4 patients (23.5%). No side effects of MTX and recurrent events were noted in any of the patients.
Conclusion:
Low-dose MTX and prednisone treatment for IGM patients, who did not respond to steroids alone, should be considered as an alternative treatment method instead of surgical intervention.
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