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Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control

Agnieszka Zubkiewicz-Kucharska1, Beata Wikiera1, Anna Noczyńska1

  • 1Department of Pediatric Endocrinology and Diabetology, Wrocław Medical University, Wrocław, Poland.

Frontiers in Endocrinology
|October 4, 2021
PubMed

Insights

Soluble Klotho protein levels are significantly lower in children with type 1 diabetes (T1D). Lower Klotho concentration in T1D is linked to HbA1c and HDL cholesterol, suggesting a role in diabetes complications.

Area of Science:

  • Endocrinology and Metabolism
  • Pediatric Nephrology
  • Molecular Biology

Background:

  • Soluble Klotho (sKlotho) may be a prognostic factor for chronic diabetes complications.
  • Decreased sKlotho concentration might contribute to beta-cell apoptosis and type 1 diabetes (T1D) development.

Purpose of the Study:

  • To evaluate sKlotho protein concentration in children with T1D.
  • To assess the correlation between sKlotho levels and risk factors for chronic diabetes complications, including dysglycemia and endothelial dysfunction.

Main Methods:

  • Cross-sectional, single-center study involving 80 children with T1D and 34 healthy controls.
  • Exclusion of micro-/macroangiopathy and confirmation of normal renal function in all participants.
  • Measurement of serum sKlotho, sICAM-1, sVCAM-1, and E-selectin levels.

Main Results:

  • Children with T1D exhibited significantly lower sKlotho concentrations compared to controls (2041.9 ± 1017.6 pg/mL vs. 2790.3 ± 1423.9 pg/mL, p=0.0113).
  • sKlotho levels correlated negatively with HbA1c (r=-0.31, P=0.0066) and positively with HDL-cholesterol (r=0.43, P=0.0011).
  • No significant correlation was found between sKlotho and diabetes duration, blood glucose parameters, or adhesion molecules (sICAM-1, sVCAM-1, E-selectin).

Conclusions:

  • Children with T1D have significantly lower sKlotho levels, which correlate with HbA1c and HDL cholesterol.
  • The negative correlation between HbA1c and sKlotho suggests a potential role of Klotho in the pathogenesis of chronic diabetes complications.
  • sKlotho levels in T1D children were not associated with endothelial dysfunction markers or disease duration.

Keywords:
Klothochildrencomplications of diabetesmetabolic controltype 1 diabetes

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