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Viruses with RNA Genomes01:29

Viruses with RNA Genomes

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RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Related Experiment Video

Updated: Oct 18, 2025

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
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Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System

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The Hepatitis B Virus Interactome: A Comprehensive Overview.

Ellen Van Damme1, Jolien Vanhove1,2, Bryan Severyn3

  • 1Janssen Research & Development, Janssen Pharmaceutical Companies, Beerse, Belgium.

Frontiers in Microbiology
|October 4, 2021
PubMed
Summary

Chronic hepatitis B (CHB) remains a global health challenge. This review details hepatitis B virus (HBV) host interactions, identifying novel therapeutic targets to achieve a functional cure for CHB.

Keywords:
HBcHBxcccDNAhepatitis B virusinteractomeviral-host life cycle

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Area of Science:

  • Virology
  • Hepatology
  • Immunology

Background:

  • Chronic hepatitis B (CHB) affects 292 million globally, with current treatments aiming for functional cure (HBsAg seroclearance and undetectable HBV-DNA).
  • Functional cure is hindered by covalently closed circular DNA (cccDNA) and integrated HBV-DNA, with the role of HBsAg from integrated DNA unclear.
  • Understanding HBV-host interactions is crucial for developing novel therapies targeting viral persistence.

Purpose of the Study:

  • To provide a comprehensive review of the hepatitis B virus (HBV) host relationship.
  • To identify novel therapeutic targets for achieving high rates of functional cure in CHB.
  • To compile an interactome of HBV cccDNA, HBc, and HBx with host proteins.

Main Methods:

  • Comprehensive literature review of HBV-host interactions from viral entry to release.
  • Analysis of viral proteins and cccDNA interactions with the host proteome.
  • Construction of an HBV interactome focusing on cccDNA, HBc, and HBx.

Main Results:

  • Detailed exploration of the virus-host relationship throughout the HBV lifecycle.
  • Identification of key viral proteins and cccDNA involved in maintaining HBV persistence and immune evasion.
  • Compilation of a novel interactome for cccDNA, HBc, and HBx, highlighting previously unknown HBV-host protein interactions.

Conclusions:

  • A deeper understanding of HBV-host interactions is essential for advancing CHB therapeutics.
  • The identified interactome provides a valuable resource for pinpointing new targets to achieve functional cure.
  • Further research into these interactions may lead to innovative strategies for HBV eradication.