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T Cell Epitope Prediction and Its Application to Immunotherapy

Anna-Lisa Schaap-Johansen1, Milena Vujović1, Annie Borch1

  • 1Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.

Frontiers in Immunology
|October 4, 2021
PubMed

T cells play a crucial role in controlling and driving the immune response with their ability to discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we focus on the currently available computational tools for epitope prediction, with a particular focus on tools aimed at identifying neoepitopes, i.e. cancer-specific peptides and their potential for use in immunotherapy for cancer treatment. This review will cover how these tools work, what kind of data they use, as well as pros and cons in their respective applications.

Keywords:
T cellT cell receptorTCRepitope predictionneoantigensneoepitope prediction

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