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Pharmacotherapeutic approach toward urological medications and vaccination during COVID-19: a narrative review
Mojtaba Shafiekhani1, Anahita Dehghani2, Mina Shahisavandi3
1Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Insights
This review examines how COVID-19 affects urologic medications for conditions like benign prostatic hyperplasia and prostate cancer, offering guidance on efficacy, side effects, and interactions.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- The COVID-19 pandemic created uncertainties regarding the management of patients with pre-existing urological conditions.
- A comprehensive understanding of the interactions between urological medications and COVID-19 infection was lacking.
Purpose of the Study:
- To review the use of urological medications in patients with COVID-19.
- To focus on efficacy, modifications, side effects, and drug interactions of urologic drugs in the context of COVID-19.
Main Methods:
- This study is a narrative review.
- It synthesizes existing literature on pharmacotherapy for common urological diseases in COVID-19 patients.
Main Results:
- The review covers medications for benign prostatic hyperplasia, prostate cancer, sexual dysfunction, urolithiasis, kidney transplantation, and hypertension.
- It discusses potential impacts on vaccination efficacy.
Conclusions:
- Clarifying the role of urological medications in COVID-19 patients is crucial for effective treatment.
- Further research is needed to fully understand drug interactions and optimize patient care.
Abstract:
One year after the prevalence of the novel coronavirus pandemic, some aspects of the physiopathology, treatment and progression of coronavirus 2019 disease (COVID-19) have remained unknown. Since no comprehensive study on the use of urological medications in patients with COVID-19 has been carried out, this narrative review aimed to focus on clinically important issues about the treatment of COVID-19 and urologic medications regarding efficacy, modifications, side effects and interactions in different urologic diseases. In this review, we provide information about the pharmacotherapeutic approach toward urologic medications in patients with COVID-19 infection. This study provides an overview of medications in benign prostatic hyperplasia, prostate cancer, impotence and sexual dysfunction, urolithiasis, kidney transplantation and hypertension as the most frequent diseases in which the patients are on long-term medications. Also, the effect of urologic drugs on the efficacy of vaccination is briefly discussed.
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Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

