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Correlation Between Serum Ferritin and Hepcidin Levels in Chronic Hepatitis C Patients

Maria Gill1, Javaria Sharafat1, Faiza Ikram1

  • 1Physiology, CMH Multan Institute of Medical Sciences, Multan, PAK.

Cureus
|October 4, 2021
PubMed

Insights

This study found no significant link between serum ferritin and hepcidin levels in chronic hepatitis C patients. Other factors, like the hepatitis C virus itself, may influence hepcidin levels.

Area of Science:

  • Hepatology
  • Immunology
  • Biochemistry

Background:

  • Serum ferritin is recognized as an inflammatory mediator.
  • The role of serum ferritin in inducing serum hepcidin requires further investigation.

Purpose of the Study:

  • To determine the correlation between serum ferritin and hepcidin levels in chronic hepatitis C (CHC) patients and healthy individuals.

Main Methods:

  • 44 male subjects were divided into healthy (n=22) and CHC patient (n=22) groups.
  • Serum hepcidin and ferritin levels were assessed.
  • Mann-Whitney U and Spearman correlation tests were used for analysis.

Main Results:

  • CHC patients showed significantly higher serum ferritin than healthy individuals (p=0.03).
  • Median serum hepcidin levels were below normal in both groups.
  • A nonsignificant negative correlation was found between serum ferritin and hepcidin in CHC patients (rho=-0.34, p=0.13).

Conclusions:

  • The study did not establish serum ferritin as a mediator for raising hepcidin in CHC patients.
  • Hepatitis C virus may play a role in reducing serum hepcidin levels, indicated by the negative correlation.

Keywords:
chronicferritinhepatitis chepcidiniron

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