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Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

Pei Dai1, Zhongxiang Tang1, Pinglang Ruan1

  • 1Department of Medical Microbiology, Xiangya School of Medicine, Central South University, Changsha, China.

Frontiers in Oncology
|October 4, 2021
PubMed
Abstract

Insights

Gimap5, a GTPase of immunity-associated protein, inhibits lung cancer growth by regulating M6PR and PADI4. This protein shows potential as a diagnostic and prognostic biomarker for lung cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • GTPases of immunity-associated proteins (GIMAPs) impact malignant cells.
  • The specific role of Gimap5 in lung cancer progression remains under-explored.

Purpose of the Study:

  • To investigate the function of Gimap5 in lung cancer development.
  • To elucidate the molecular mechanisms by which Gimap5 influences lung cancer cells.

Main Methods:

  • Analyzed GIMAP family expression in lung cancer patient databases and cell lines.
  • Assessed the impact of Gimap5 overexpression on lung cancer cell migration, invasion, proliferation, and epithelial-mesenchymal transition (EMT).
  • Identified Gimap5 interacting proteins using Co-IP and mass spectrometry; analyzed M6PR and PADI4 expression and localization.

Main Results:

  • GIMAP family expression was significantly downregulated in lung cancer, correlating with poor prognosis.
  • Gimap5 overexpression inhibited lung cancer cell migration, invasion, proliferation, and EMT.
  • Gimap5 promoted M6PR transport to the cell membrane, suppressing EMT-associated PADI4 activity.

Conclusions:

  • Gimap5 inhibits lung cancer growth through M6PR interaction.
  • Gimap5 holds potential as a biomarker for lung cancer diagnosis and prognosis.
Keywords:
GIMAP5M6PRPADI4lung cancerpotential biomarkerprognosis

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