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Immune Infiltration of MMP14 in Pan Cancer and Its Prognostic Effect on Tumors
Minde Li1, Shaoyang Li1, Lin Zhou1
1Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Background:
Matrix metalloproteinase 14 (MMP14) is a member of the MMP family, which interacts with tissue inhibitors of metalloproteinase (TIMPs), and is involved in normal physiological functions such as cell migration, invasion, metastasis, angiogenesis, and proliferation, as well as tumor genesis and progression. However, there has been a lack of relevant reports on the effect of MMP14 across cancers. This study aims to explore the correlation between MMP14 and pan-cancer prognosis, immune infiltration, and the effects of pan-cancer gene mismatch repair (MMR), microsatellite instability (MSI), tumor mutational burden (TMB), DNA methylation, and immune checkpoint genes.
Methods:
In this study, we used bioinformatics to analyze data from multiple databases, including The Cancer Genome Atlas (TCGA), ONCOMINE, and Kaplan-Meier plotter. We investigated the relationship between the expression of MMP14 in tumors and tumor prognosis, the relationship between MMP14 expression and tumor cell immune infiltration, and the relationship between MMR gene MMR, MSI, TMB, DNA methylation, and immune checkpoint genes.
Results:
MMP14 expression is highly associated with the prognosis of a variety of cancers and tumor immune invasion and has important effects on pan oncologic MMR, MSI, TMB, DNA methylation, and immune checkpoint genes.
Conclusion:
MMP14 is highly correlated with tumor prognosis and immune invasion and affects the occurrence and progression of many tumors. All of these results fully indicate that MMP14 may be a biomarker for the prognosis, diagnosis, and treatment of many tumors and provide new ideas and direction for subsequent tumor immune research and treatment strategies.
Insights
Matrix metalloproteinase 14 (MMP14) is linked to cancer prognosis and immune infiltration across many cancer types. This study suggests MMP14 may serve as a biomarker for cancer diagnosis and treatment.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Matrix metalloproteinase 14 (MMP14) is involved in cell migration, invasion, metastasis, angiogenesis, and proliferation.
- MMP14 plays a role in tumor genesis and progression.
- Limited research exists on MMP14's pan-cancer effects.
Purpose of the Study:
- To investigate the correlation between MMP14 expression and pan-cancer prognosis.
- To explore MMP14's relationship with tumor immune infiltration.
- To analyze MMP14's association with mismatch repair (MMR), microsatellite instability (MSI), tumor mutational burden (TMB), DNA methylation, and immune checkpoint genes.
Main Methods:
- Bioinformatic analysis using The Cancer Genome Atlas (TCGA), ONCOMINE, and Kaplan-Meier plotter databases.
- Investigated MMP14 expression in relation to tumor prognosis and immune cell infiltration.
- Examined the link between MMP14 and MMR, MSI, TMB, DNA methylation, and immune checkpoint genes.
Main Results:
- MMP14 expression is significantly associated with prognosis in various cancers.
- MMP14 expression correlates with tumor immune invasion.
- MMP14 influences pan-cancer MMR, MSI, TMB, DNA methylation, and immune checkpoint genes.
Conclusions:
- MMP14 is highly correlated with tumor prognosis and immune invasion.
- MMP14 impacts the occurrence and progression of numerous tumors.
- MMP14 shows potential as a biomarker for cancer prognosis, diagnosis, and treatment, offering new avenues for immune research.
