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Successful Treatment of Late Isolated Bone Metastasis in a Patient with Bilateral Retinoblastoma Using an
Deepthi Boddu1, Priyakumari Thankamony1, Reshma Prakasam2
1Department of Paediatric Oncology, Regional Cancer Centre, Thiruvananthapuram, India.
Insights
Bilateral retinoblastoma (RB) treatment can lead to long-term survival, but metastatic recurrence is possible. This case highlights successful treatment of isolated bone relapse in a retinoblastoma survivor.
Area of Science:
- Pediatric Oncology
- Ophthalmology
- Cancer Metastasis
Background:
- Bilateral retinoblastoma (RB) survival rates have improved with advanced diagnostics and treatments.
- Long-term surveillance is crucial for detecting recurrence and secondary malignancies in RB survivors.
Observation:
- A 7-month-old infant with bilateral retinoblastoma achieved complete tumor regression after chemotherapy, transpupillary thermotherapy, and periocular carboplatin.
- Six and a half years post-treatment, the patient developed a metastatic recurrence in the left ulna.
Findings:
- The metastatic bone relapse was successfully managed using chemotherapy, extracorporeal radiation, and reimplantation therapy.
- This case demonstrates the feasibility of limb salvage for isolated bone metastasis in retinoblastoma.
Implications:
- A less aggressive treatment strategy may be considered for selected cases of isolated bone relapse in retinoblastoma survivors.
- This approach could improve quality of life and functional outcomes for pediatric cancer patients.
Abstract:
Though survival in bilateral retinoblastoma (RB) has improved due to advancement in diagnostics and treatment modalities, children require long-term follow-ups for recurrence and second malignancies. We report a case of bilateral RB in a 7-month-old baby who was treated with chemotherapy, transpupillary thermotherapy, and periocular carboplatin for both eyes following which there was complete regression of tumour. Six and a half years after treatment, the child presented with metastatic recurrence of tumour in the left ulna. He was treated successfully with chemotherapy, extracorporeal radiation and reimplantation therapy. A less aggressive treatment approach for isolated bone relapse may be considered in selected cases.
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