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The Application of Microfluidic Technologies in Aptamer Selection.

Yang Liu1,2, Nijia Wang1,2, Chiu-Wing Chan1

  • 1Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong, SAR China.

Frontiers in Cell and Developmental Biology
|October 4, 2021
PubMed
Summary
This summary is machine-generated.

Microfluidic technologies offer a faster, automated approach to selecting aptamers, which are DNA or RNA molecules used in diagnostics and therapeutics. This review details advancements in microfluidic systems for efficient aptamer selection.

Keywords:
SELEXaptamermicroarraymicrofluidicsoligonucleotide

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Analytical Chemistry

Background:

  • Aptamers are single-strand oligonucleotides with specific target-binding capabilities.
  • They are crucial for analysis, diagnostics, and medical treatments.
  • Conventional aptamer selection (SELEX) is labor-intensive and inefficient.

Purpose of the Study:

  • To review microfluidic systems for aptamer selection.
  • To compare the performance of different microfluidic-based aptamer selection methods.
  • To discuss the principles, structures, operations, advantages, and limitations of these systems.

Main Methods:

  • Review of current literature on microfluidic aptamer selection systems.
  • Comparative analysis of various microfluidic SELEX approaches.
  • Discussion of technological advancements and challenges.

Main Results:

  • Microfluidic technologies offer low cost, high speed, and automation for aptamer selection.
  • These systems significantly improve efficiency and success rates compared to conventional methods.
  • Various microfluidic platforms have been developed, each with unique benefits and drawbacks.

Conclusions:

  • Microfluidic systems represent a promising advancement for rapid and high-throughput aptamer selection.
  • Further development can overcome limitations and expand aptamer applications.
  • These technologies are key to realizing the full potential of aptamers in medicine and diagnostics.