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A structured model for immobilized cell kinetics.

H G Monbouquette, D F Ollis

    Annals of the New York Academy of Sciences
    |January 1, 1986
    PubMed
    Summary
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    A new model describes living cells in porous supports, matching literature on cell growth and substrate use. Carrier pore structure is key for optimizing biocatalyst design.

    Area of Science:

    • Biochemical Engineering
    • Biocatalysis
    • Biotechnology

    Background:

    • Immobilized cell systems are crucial for biocatalysis.
    • Understanding cell kinetics within porous supports is essential for process optimization.
    • Existing models may not fully capture the interplay of pore structure and cell behavior.

    Purpose of the Study:

    • To develop an intrinsic, structured model for viable cell kinetics in porous supports.
    • To predict internal biomass concentration, substrate profiles, and cell leakage.
    • To identify critical design parameters for immobilized biocatalyst development.

    Main Methods:

    • Formulation of a structured mathematical model.
    • Simulation of steady-state conditions.

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  • Analysis of biomass concentration, substrate profiles, and cell growth/leakage.

    • Main Results:

    • Model predictions show qualitative agreement with existing literature.
    • The model successfully describes internal biomass distribution and substrate profiles.
    • Cell growth and leakage dynamics within the support were simulated.

    Conclusions:

    • The developed model provides a framework for understanding immobilized cell kinetics.
    • Carrier pore structure significantly influences biocatalyst performance.
    • Optimization of pore structure is a critical factor for designing efficient immobilized cell systems.