Luminescent Covalent Organic Frameworks for Biosensing and Bioimaging Applications

Area of Science:

• Materials Science
• Chemistry
• Biotechnology

Background:

• Luminescent covalent organic frameworks (LCOFs) are highly ordered, periodic structures built from luminophore units.
• Their tunable properties, biocompatibility, and tumor penetration enable biorelated applications.
• A comprehensive review of LCOFs in biosensing and bioimaging is needed.

Purpose of the Study:

• To review the construction and synthetic chemistry of LCOFs.
• To discuss strategies for enhancing LCOF luminescence.
• To explore LCOF applications in biosensing and bioimaging with examples.

Main Methods:

• Review of existing literature on LCOF synthesis and characterization.
• Analysis of structure-property relationships in LCOFs.
• Case studies of LCOF applications in biosensing and bioimaging.

Main Results:

• Chemical linkages are crucial for LCOF construction, optical properties, and sensing capabilities.
• Structure management strategies can significantly enhance LCOF luminescence.
• LCOFs demonstrate promising performance in biosensing and bioimaging applications.

Conclusions:

• LCOFs offer versatile platforms for advanced biosensing and bioimaging.
• Further research is needed to address challenges in LCOF development from chemistry to application.
• The review provides insights into opportunities and future directions for LCOF research.