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Updated: Oct 18, 2025

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
A guide to Hodgkin and non-Hodgkin lymphomas: similarities and differences
Fiona Holdsworth1, Dominic Worku2, Alanna le Bretton2
1Oncology Nurse Practitioner and Lecturer for Newcastle University.
Insights
This review compares Hodgkin lymphoma and non-Hodgkin lymphoma, highlighting key differences in age of presentation and subtypes. Understanding these common hematology diagnoses is crucial for all healthcare professionals.
Area of Science:
- Hematology
- Oncology
- Internal Medicine
Background:
- COVID-19 pandemic underscores the need for robust knowledge of cancer care.
- Hodgkin lymphoma and non-Hodgkin lymphoma are common hematological malignancies.
- General practitioners and non-cancer specialists frequently encounter these conditions.
Purpose of the Study:
- To review and compare Hodgkin lymphoma and non-Hodgkin lymphoma.
- To inform healthcare professionals about the characteristics, prognostics, and treatment of these lymphomas.
- To emphasize the importance of awareness for all health professionals, including nurses.
Main Methods:
- Literature review of Hodgkin lymphoma and non-Hodgkin lymphoma.
- Comparative analysis of disease processes, symptoms, prognostics, and treatments.
- Discussion of diagnostic investigations and age of presentation.
Main Results:
- Hodgkin lymphoma and non-Hodgkin lymphoma share similarities in presentation and diagnostic investigations.
- Significant differences exist in age of presentation and the number of subtypes.
- Prognostics and treatment pathways also present notable contrasts.
Conclusions:
- Awareness of lymphoma characteristics is vital for all healthcare providers.
- Understanding the similarities and differences aids in accurate diagnosis and management.
- This review provides essential knowledge for managing patients with these hematological malignancies.
Abstract:
In the extraordinary times the COVID-19 pandemic has created for cancer patients and the health professionals caring for them, the need for strong knowledge and understanding of disease processes and treatments has never been more important. This article presents a review of Hodgkin lymphoma and non-Hodgkin lymphoma. These two common haematology diagnoses are frequently suspected by GPs and non-cancer professionals, and subsequently treated by haematologists and chemotherapy outpatient departments across the country. It is therefore important for all health professionals, including nurses in all settings, to be aware of the main characteristics of both of these lymphomas. There are strong similarities and striking differences between the disease processes, the presenting symptoms, prognostics and treatment pathways. The age of presentation in each is markedly different. There is a significant contrast in the number of subtypes between the two diagnoses, but the presenting symptoms are similar as are investigations required for diagnoses.
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