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Kikuchi-Fujimoto Disease Associated With Mycoplasma Pneumoniae Infection

Rui-Bin Yu1,2, Yi-Jia Chen1, Chun-Hsiang Chang1,2,3

  • 1Department of Otolaryngology-Head and Neck Surgery, Catholic Cardinal Tien Hospital, New Taipei City, Taiwan ROC.

Ear, Nose, & Throat Journal
|October 4, 2021
PubMed

Insights

Kikuchi-Fujimoto disease (KFD) in two patients was linked to Mycoplasma pneumoniae infection. Successful treatment was achieved using a macrolide antibiotic, suggesting a potential therapeutic role.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pathology

Background:

  • Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting condition primarily affecting young women, characterized by fever and lymphadenopathy.
  • The exact cause of KFD remains unknown, with diagnosis relying on lymph node biopsy.
  • Previous reports suggest a possible association between KFD and Mycoplasma pneumoniae infection, but the efficacy of antibiotic therapy is not well-established.

Purpose of the Study:

  • To investigate the association between Kikuchi-Fujimoto disease and Mycoplasma pneumoniae infection.
  • To evaluate the effectiveness of macrolide antibiotic treatment in KFD cases associated with Mycoplasma pneumoniae.

Main Methods:

  • Case report of two patients diagnosed with Kikuchi-Fujimoto disease.
  • Diagnostic confirmation through lymph node biopsy.
  • Treatment administered included macrolide antibiotics for Mycoplasma pneumoniae infection.

Main Results:

  • Both reported cases presented with symptoms consistent with KFD.
  • Mycoplasma pneumoniae infection was identified in association with KFD in both patients.
  • Successful clinical recovery was observed in both cases following macrolide antibiotic treatment.

Conclusions:

  • Mycoplasma pneumoniae infection may be implicated in the pathogenesis of Kikuchi-Fujimoto disease.
  • Macrolide antibiotics appear to be an effective treatment option for KFD associated with Mycoplasma pneumoniae infection.
Keywords:
Kikuchi–Fujimoto diseasemacrolidemycoplasma pneumoniaenecrotizing lymphadenitis

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