Customized materials-assisted microorganisms in tumor therapeutics

Area of Science:

• Biotechnology
• Oncology
• Microbiology

Background:

• Microorganisms are utilized as biotherapeutic agents and drug delivery systems for cancer treatment.
• Living attributes of microorganisms offer novel approaches in anticancer research.
• Integrating functional materials with microorganisms enhances antitumor capabilities.

Purpose of the Study:

• To review the development of customized materials-assisted microorganisms (MAMO) for tumor therapeutics.
• To emphasize the rational use of microorganisms and tailored materials in biohybrid systems.
• To discuss the antitumor mechanisms and future perspectives of MAMO in cancer therapy.

Main Methods:

• Literature review on materials-assisted microorganism (MAMO) applications in tumor therapy.
• Analysis of rational utilization of microorganisms and tailored materials.
• Examination of biohybrid system designs and antitumor mechanisms.

Main Results:

• Customized materials significantly enhance the antitumor efficacy of microorganisms.
• Biohybrid systems demonstrate unprecedented potential in solving existing challenges in tumor therapy.
• Various microorganisms (bacteria, viruses, fungi, microalgae) and their components are explored.

Conclusions:

• Materials-assisted microorganisms (MAMO) represent a promising strategy for advanced tumor therapeutics.
• Ingenious biohybrid designs and rational material selection are key to efficacy.
• Further research is needed to address challenges and fully realize the potential of MAMO.