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Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
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Early decrease in lean mass and bone mass in postmenopausal women: a cross-sectional study.

J Zandoná1,2, C F Ferreira1,2, P G de Oliveira2,3

  • 1Programa de Pós-Graduação em Ciências da Saúde: Ginecologia e Obstetrícia (PPGGO), Hospital de Clínicas de Porto Alegre (HCPA), Faculdade de Medicina (FAMED), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil.

Climacteric : the Journal of the International Menopause Society
|October 5, 2021
PubMed
Summary
This summary is machine-generated.

Menopause transition leads to decreased lean and bone mass, and increased lipids. Early postmenopause offers a key window to prevent obesity, cardiovascular risk, and osteoporosis.

Keywords:
Body compositionclimactericdual-energy X-ray absorptiometry scanmenopause

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Area of Science:

  • Endocrinology and Metabolism
  • Human Physiology
  • Women's Health

Background:

  • Menopause transition significantly impacts women's health.
  • Understanding changes in body composition during this phase is crucial for health management.

Purpose of the Study:

  • To evaluate the effects of menopause transition on body composition.
  • To identify potential health risks associated with these changes.

Main Methods:

  • Cross-sectional study in Brazil with premenopausal and postmenopausal women (aged 44-52).
  • Data collected via questionnaires (sociodemographic, Menopause Rating Scale, physical activity, appetite), 24-hour dietary recall.
  • Body composition assessed using anthropometry, densitometry, and blood biochemical analyses.

Main Results:

  • Most participants were overweight or obese and highly active.
  • Lean mass and bone mass decreased post-menopause.
  • Increased total and high-density lipoprotein cholesterol observed.
  • Body fat distribution remained unchanged; total and regional fat correlated with smoking and waist circumference.

Conclusions:

  • Early postmenopause is a critical period for intervention.
  • Opportunities exist to prevent atherogenic profiles, obesity, cardiovascular risk, and osteoporosis.