Related Experiment Video
Updated: Oct 18, 2025
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
1.2K
Lipid-based emulsion drug delivery systems - a comprehensive review
Mori Dhaval1, Poonam Vaghela2, Kajal Patel2
1B.K. Mody Government Pharmacy College, Polytechnic Campus, Near Ajidam, Rajkot, Gujarat, India. dhavaldmori@gmail.com.
Drug Delivery and Translational Research
|October 5, 2021
Summary
Lipid-based emulsion systems enhance solubility and bioavailability for poorly soluble drugs. This review details microemulsions, nanoemulsions, and self-emulsifying systems, clarifying their properties and applications.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Rising number of water-insoluble drug candidates necessitate advanced delivery systems.
- Lipid-based emulsion systems offer improved solubility, permeability, and protection against metabolism.
- Ease of manufacturing and scalability contribute to the popularity of these systems.
Purpose of the Study:
- To provide a comprehensive review of lipid-based emulsion systems.
- To elucidate the properties, preparation, and evaluation of microemulsions, nanoemulsions, self-microemulsifying drug delivery systems (SMEDDS), and self-nanoemulsifying drug delivery systems (SNEDDS).
- To clarify distinctions between similar terminologies and discuss excipient selection and modification.
Main Methods:
- Literature review of lipid-based emulsion technologies.
- Comparative analysis of microemulsions, nanoemulsions, SMEDDS, and SNEDDS.
- Discussion of stabilization mechanisms, preparation methods, and evaluation techniques.
- Exploration of lipidic excipient structures, modifications, and regulatory aspects.
Main Results:
- Lipid-based systems significantly enhance drug solubility and bioavailability.
- Detailed comparison highlights similarities and differences between various emulsion types.
- Understanding of stabilization mechanisms, preparation, and characterization is crucial for rational design.
- Information on excipient properties and regulatory status aids in formulation development.
Conclusions:
- Lipid-based emulsion systems are versatile and effective for improving the delivery of poorly soluble drugs.
- This review offers a detailed guide to understanding and utilizing these advanced drug delivery platforms.
- Informed selection and modification of lipidic excipients are key for successful formulation development.
Related Concept Videos
01:27Bioavailability Enhancement: Drug Permeability Enhancement
20
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
20
01:16Drug Delivery: Overview
477
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
477
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
20
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
20
01:16Bioavailability Enhancement: Drug Solubility Enhancement
18
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
18
01:22Drug Delivery: Miscellaneous Routes
541
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
541
01:18Drug Delivery: Enteral Route
871
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
871