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Chitosan-based multifunctional flexible hemostatic bio-hydrogel.

Fuyu Song1, Yue Kong1, Changyou Shao1

  • 1Liaoning Key Laboratory of Lignocellulose Chemistry and BioMaterials, School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, China.

Acta Biomaterialia
|October 5, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a flexible, self-adhesive chitosan hydrogel for rapid hemostasis. This advanced biomaterial offers superior blood absorption, strong adhesion in wet conditions, and faster clotting than commercial options, paving the way for improved wound care.

Keywords:
BiocompatibilityDegradabilityHemostatic bio-hydrogelModified chitosanSelf-adhesiveSelf-healingStretchability

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Chitosan shows promise as a biomedical hemostatic agent.
  • Developing flexible chitosan hydrogels with self-adhesion and rapid hemostasis is challenging.

Purpose of the Study:

  • To create a chitosan-based hemostatic bio-hydrogel with self-adhesion, flexibility, and rapid hemostasis.
  • To investigate the material properties and in vivo hemostatic performance of the developed hydrogel.

Main Methods:

  • Fabrication of chitosan-based hydrogels (DCS-PEGSH gels) using modified chitosan (DCS) and polyethylene glycol (PEGSH).
  • Characterization of hydrogel properties including cytocompatibility, stretchability, blood absorbability, and adhesion.
  • Evaluation of hemostatic efficacy in vitro (clotting time, clotting index) and in vivo (blood loss in mice).

Main Results:

  • The DCS-PEGSH hydrogels exhibited excellent stretchability (~780%) and blood absorbability (1300% ± 50%).
  • Strong adhesion (~68.5 kPa) ensured stable performance in humid environments.
  • The hydrogels demonstrated significantly faster blood clotting (50 s) and reduced blood loss (~90% in mice) compared to controls.

Conclusions:

  • The developed chitosan-based hydrogel offers a promising solution for biomedical hemostasis.
  • Its unique properties, including self-adhesion, stretchability, and rapid hemostasis, enable effective application in challenging wound conditions.
  • This study provides a foundation for advanced chitosan biomaterials in emergency medicine.