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The relationship between directly measured statin adherence, self-reported adherence measures and cholesterol levels

Oscar Kristiansen1, Elise Sverre1, Kari Peersen2

  • 1Department of Medicine, Drammen Hospital, Vestre Viken Trust, Dronninggata 28, 3004, Drammen, Norway; Department of Behavioral Medicine, Faculty of Medicine, University of Oslo, Domus Medica, Sognsvannsveien 9, 0372, Oslo, Norway.

Atherosclerosis
|October 5, 2021
PubMed

Insights

Directly measuring statin adherence in plasma is more sensitive than self-report. This method correlates with cholesterol levels, offering a valuable tool for improving lipid management in patients.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Statin adherence is crucial for managing cardiovascular health.
  • Accurate measurement of statin adherence is challenging with current self-report methods.
  • Understanding the relationship between adherence and cholesterol levels is vital for patient outcomes.

Purpose of the Study:

  • To determine the relationship between directly measured statin adherence and self-report measures.
  • To assess the correlation between statin adherence and serum cholesterol levels.
  • To evaluate the utility of plasma-statin measurement for assessing adherence.

Main Methods:

  • A cross-sectional study of 373 patients prescribed atorvastatin post-coronary event.
  • Direct measurement of atorvastatin in plasma using liquid chromatography-tandem mass spectrometry.
  • Comparison with self-reported adherence using various scales (past week, MMAS-8, Gehi question).

Main Results:

  • Direct plasma measurement revealed 8% reduced atorvastatin adherence.
  • Self-report measures showed lower sensitivity in detecting reduced adherence compared to direct measurement.
  • Directly measured adherence and some self-report measures were inversely related to LDL-cholesterol levels (p<0.001).

Conclusions:

  • Plasma-statin measurement offers higher sensitivity for detecting reduced adherence than self-report.
  • Direct adherence measurement correlates with cholesterol levels, aiding lipid management.
  • This method may serve as a valuable tool for optimizing patient lipid profiles.
Abstract

Keywords:
AdherenceAtorvastatinCoronary heart diseaseLiquid chromatography tandem mass spectrometry

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