Applicability of quantitative oculomotor and SARA assessment in children

In clinical practice, eye movements can provide an early diagnostic marker for early onset ataxia (EOA). However, quantitative oculomotor assessment is not included in the most frequently used and age-validated ataxia rating scale in children, the Scale for the Assessment and Rating of Ataxia (SARA). We aimed to investigate the applicability of semi-quantitative eye movement assessment by the International Cooperative Ataxia Rating Scale (ICARS_OCM) and Ocular Motion Score (OMS_7-10) complementary to SARA measurements in children.

In 52 typically developing children (aged 4-16 years; n = 4 per year of age), three independent assessors scored saccadic eye movements and ocular pursuit according to the ICARS_OCM and matching parameters from the OMS_7-10. For ICARS_OCM, we determined 1) construct validity for coordinated eye movements by correlation with OMS_7-10, ICARS_{EYE-HAND-COORDINATION} and SARA subscale scores, 2) agreement percentage and inter-rater agreement (Fleiss Kappa) and 3) age-dependency.

Spearman's rank correlations of ICARS_OCM with OMS_7-10 and ICARS- and SARA subscales were moderate to fair (all p < .001). Inter-rater agreement of ICARS-_OCM was 80.8%; (Fleiss Kappa: 0.411). ICARS_OCM scores revealed a similar exponentially decreasing association with age as the other SARA (sub)scores, reaching a plateau at 10 years of age.

ICARS_OCM has a valid construct for the measurement of coordinated eye movement performance and is reliably assessable in children. ICARS_OCM reveals a similar age-dependent relationship as the other ataxia subscales, reflecting the physiological maturation of the cerebellum. In children, these data may implicate that ICARS_OCM can reliably contribute to coordination assessment, complementary to the SARA subscales.