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Sortilin and Homocysteine as Potential Biomarkers for Coronary Artery Diseases
Rehab H Werida1, Ayman Omran2, Noha M El-Khodary1
1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
Insights
Elevated homocysteine and sortilin levels are key risk factors for coronary artery disease (CAD) in Egyptian patients. This study highlights their association with CAD, emphasizing their importance in cardiac risk assessment.
Area of Science:
- Cardiology
- Biochemistry
- Clinical Research
Background:
- Coronary artery disease (CAD) is a leading global cause of mortality.
- Understanding CAD risk factors is crucial for effective prevention and treatment strategies.
Purpose of the Study:
- To investigate the association between coronary artery disease (CAD) and the levels of homocysteine and sortilin in an Egyptian population.
- To identify potential biomarkers for CAD risk in this demographic.
Main Methods:
- A cohort of 45 Egyptian patients diagnosed with CAD via coronary CT angiography was compared to 42 healthy controls.
- Plasma levels of homocysteine and sortilin were quantified using a commercial ELISA kit.
Main Results:
- Patients with CAD exhibited significantly higher levels of homocysteine and sortilin compared to controls.
- CAD patients also showed dyslipidemia, with higher total cholesterol, LDL, and triglycerides, and lower HDL.
- Sortilin levels demonstrated positive correlations with homocysteine, lipids, troponin I, Gensini score, and hs-CRP.
Conclusions:
- Elevated homocysteine and sortilin are identified as significant risk factors for coronary artery disease (CAD) in Egyptian patients.
- These findings suggest that homocysteine and sortilin may serve as important biomarkers for CAD risk.
Purpose:
The aim of this study was to assess the relationship of coronary artery disease (CAD) with levels of homocysteine and sortilin in Egyptian patients.
Background:
CAD is a primary contributor to cardiac disease and a prominent cause of death globally.
Patients And Methods:
We enrolled 45 patients with CAD evaluated by coronary CT angiography and 42 control subjects without CAD. Plasma-homocysteine and -sortilin levels were measured with a commercial ELISA kit.
Results:
Elevated levels of homocysteine and sortilin were observed in the CAD patients compared to controls (13.75±1.40 vs 7.73±2.06 μmol/L, P=0 and 160.91±32.17 vs 143.02±32.30 ng/dL, P=0.02, respectively). Significantly higher total cholesterol, low density-lipoprotein cholesterol and triglycerides (P<0.05) and lower high density-lipoprotein cholesterol (P<0.05) were seen among patients with CAD than the control group. Sortilin levels were positively associated with homocysteine levels (r=0.32, P=0.006), total cholesterol (r=0.61, P=0), low density-lipoprotein cholesterol (r=0.37, P=0.001), triglycerides (r=0.91, P=0), troponin I (r=0.82, P=0), Gensini score (r=0.93, P=0) and high-sensitivity CRP (r=0.87, P=0) in all subjects. Homocysteine has a significantly negative association with high density-lipoprotein cholesterol (r=-0.42, P=0).
Conclusion:
Elevated homocysteine and sortilin levels are crucial risk factors of CAD in Egyptian patients.
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