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Amyloid-β PET Classification on Cognitive Aging Stages Using the Centiloid Scale.

Giordana Salvi de Souza1,2, Michele Alberton Andrade3,4,5, Wyllians Vendramini Borelli5

  • 1School of Medicine, PUCRS, Porto Alegre, Brazil. giordana.souza@edu.pucrs.br.

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Summary

The Centiloid method for amyloid-β PET quantification shows SuperAgers have similar amyloid-β loads to controls, but cognitive differences persist. Varying cut-points for amyloid-β positivity can lead to classification mismatches, especially between 10-30 CL values.

Keywords:
11C-PiBDiagnostic imagingHealthy agingPositron emission tomographySuperAgers

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Area of Science:

  • Neuroimaging and diagnostics
  • Cognitive aging research
  • Alzheimer's disease biomarkers

Background:

  • Amyloid-β (Aβ) PET imaging is crucial for Alzheimer's disease (AD) diagnosis.
  • The Centiloid (CL) method standardizes Aβ quantification across PET imaging centers.
  • Understanding Aβ burden in different cognitive aging trajectories, including SuperAgers (SA), is essential.

Purpose of the Study:

  • To evaluate the Centiloid (CL) method for amyloid-β PET quantification in distinct cognitive aging stages.
  • To investigate classification mismatches in amyloid-β positivity using different CL cut-points.
  • To compare Aβ burden across SuperAgers (SA), age-matched controls (AC), middle-aged controls (MC), and Alzheimer's disease (AD) groups.

Main Methods:

  • Applied the CL equation to quantify Aβ burden in SA, AC, MC, and AD groups.
  • Utilized three established cut-points (10, 19, and 30 CL) to define Aβ positivity.
  • Correlated CL values with visual reads, RAVLT delayed recall (DR), and Mini-Mental State Examination (MMSE) scores.

Main Results:

  • AD group showed significantly higher Aβ burden than MC, but not AC.
  • No significant difference in Aβ burden was found between AC and MC groups.
  • CL values moderately correlated with Aβ visual read, RAVLT DR, and MMSE.
  • Using different cut-points resulted in classification mismatches for 7.5% of individuals; 40-60% of AC were classified as positive.

Conclusions:

  • SuperAgers exhibit similar Aβ loads to controls despite cognitive performance differences.
  • Three SA individuals were classified as Aβ positive, highlighting the clinicobiological duality in Alzheimer's.
  • The choice of CL cut-point impacts Aβ positivity classification, necessitating caution for values between 10-30 CL.