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Histopathologic features of inverse psoriasis
Michael Knabel1, Kumaran Mudaliar2
1Division of Dermatology, Loyola University Medical Center, Maywood, Illinois, USA.
Journal of Cutaneous Pathology
|October 6, 2021
Summary
Inverse psoriasis often shows classic psoriasis features, but atypical findings like spongiosis and eosinophils are also common. This study investigated the histopathology of inverse psoriasis in intertriginous areas.
Area of Science:
- Dermatology
- Pathology
Background:
- Inverse psoriasis, a form of psoriasis in skin folds, is understudied.
- Histopathologic features of inverse psoriasis are often grouped with plaque psoriasis.
Purpose of the Study:
- To investigate the histopathologic features of inverse psoriasis.
- To compare inverse psoriasis findings with classic plaque psoriasis.
Main Methods:
- Retrospective cohort study of biopsy slides from patients with inverse psoriasis.
- Review of patient charts to confirm clinical diagnosis.
Main Results:
- 12 patients included; classic psoriasis features (hypogranulosis, parakeratosis) present in 100%.
- Atypical features observed: spongiosis (83%), eosinophils (67%), focal serum (42%).
- Neutrophils present in scale (83%) and dermis (100%).
Conclusions:
- Inverse psoriasis shares classic psoriasis histopathology.
- Atypical features like spongiosis, eosinophils, and serum are common in inverse psoriasis.
- These findings highlight unique histopathologic aspects of inverse psoriasis.
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