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Related Experiment Video

Updated: Oct 17, 2025

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Circulating choline pathway nutrients and depression after ischemic stroke.

Mengyuan Miao1, Jigang Du1, Bizhong Che1

  • 1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.

European Journal of Neurology
|October 6, 2021
PubMed
Summary
This summary is machine-generated.

Higher levels of choline and betaine may reduce the risk of poststroke depression (PSD). This study found lower nutrient levels in patients with depression after ischemic stroke, suggesting a protective role for these nutrients.

Keywords:
betainecholineischemic strokepoststroke depression

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Area of Science:

  • Nutritional Neuroscience
  • Stroke Psychiatry

Background:

  • Choline pathway nutrients, including choline and betaine, are known for potential antidepressant effects.
  • Limited population-based evidence exists linking circulating choline and betaine to poststroke depression (PSD).
  • This study addresses the gap by examining these associations prospectively.

Purpose of the Study:

  • To prospectively investigate the association between plasma choline and betaine concentrations and depression following ischemic stroke.
  • To evaluate the potential of choline and betaine as biomarkers for predicting poststroke depression risk.

Main Methods:

  • Utilized data from the China Antihypertensive Trial in Acute Ischemic Stroke, including 612 participants.
  • Measured plasma concentrations of choline and betaine.
  • Assessed depression 3 months post-ischemic stroke using logistic regression models, including risk reclassification analyses.

Main Results:

  • Patients with poststroke depression exhibited significantly lower plasma choline and betaine levels compared to those without depression.
  • Higher tertiles of choline and betaine were associated with reduced odds of PSD (ORs 0.54 and 0.59, respectively).
  • Each standard deviation increase in choline or betaine correlated with a significant decrease in PSD risk (25% and 19%, respectively).
  • Inclusion of choline or betaine improved the predictive models for PSD risk.

Conclusions:

  • Elevated plasma levels of choline and betaine are linked to a lower risk of depression after acute ischemic stroke.
  • Choline pathway nutrients demonstrate protective significance against poststroke depression.
  • These findings highlight the potential role of nutritional interventions targeting choline and betaine in managing PSD.