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Updated: Oct 17, 2025
Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Multicenter real-world experience with epinephrine 0.5 mg dosing for anaphylaxis with allergen immunotherapy
Natasha Correa1, Ariba Quidwai2, Samira Jeimy1
1Division of Clinical Immunology & Allergy, Department of Medicine, Western University, London, ON, N6A 4V2, Canada.
Abstract:
Aim: To determine the safety and efficacy of 0.5 mg intramuscular (IM) epinephrine for the treatment of subcutaneous allergen immunotherapy induced anaphylaxis. Patients & methods: Retrospective chart review of patients who received 0.5 mg of IM epinephrine for treatment of anaphylaxis from subcutaneous allergen immunotherapy at two outpatient allergy and immunology practices. Results: Thirty-eight patients received 0.5 mg IM epinephrine. Eleven patients (29%) required a second dose, and two patients (5%) required a third dose of IM epinephrine. Sixteen patients (42%) were transferred to the emergency department with ongoing symptoms. All had eventual resolution of anaphylaxis. There were no adverse reactions or fatalities. Conclusion: IM epinephrine at a dose of 0.5 mg is safe and effective for treatment of anaphylaxis from subcutaneous allergen immunotherapy.
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