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CpxM(iii)-catalyzed enantioselective C-H functionalization through migratory insertion of metal-carbenes/nitrenes
Chongqing Pan1, Si-Yong Yin, Qing Gu
1State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China. slyou@sioc.ac.cn.
Abstract:
CpxM(iii)-catalyzed enantioselective C-H functionalization reactions have progressed rapidly using either chiral cyclopentadienyl ligands or appropriate chiral carboxylic acids. In this context, highly reactive carbene and nitrene precursors can serve as effective C-H coupling partners, providing a straightforward and efficient approach to access chiral molecules. In this review, we highlight the developments in CpxM(iii)-catalyzed enantioselective C-H functionalization reactions through migratory insertion of metal-carbenes/nitrenes by employing chiral CpxM(iii) complexes or achiral CpxM(iii) complexes combined with chiral carboxylic acids.
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