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Crosslinking Trends in Multicomponent Hydrogels for Biomedical Applications.

Jagan Mohan Dodda1, Mina Ghafouri Azar1, Rotimi Sadiku2

  • 1New Technologies-Research Centre (NTC), University of West Bohemia, Univerzitní 8, Pilsen, 301 00, Czech Republic.

Macromolecular Bioscience
|October 6, 2021
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Summary

This review explores multicomponent hydrogels for biomedical uses. It focuses on physical, chemical, and enzymatic crosslinking methods crucial for advanced material design and drug delivery systems.

Keywords:
crosslinkinghydrogelshydrogen bondingmulticomponentnetwork formationself-assembly

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Multicomponent hydrogels are promising for biomedical applications.
  • Challenges exist in crosslinking, network formation, and component incorporation.
  • Understanding crosslinking mechanisms is vital for hydrogel engineering.

Purpose of the Study:

  • To review recent advances in crosslinking methods for multicomponent hydrogels.
  • To highlight the importance of crosslinking types and network formation.
  • To address the lack of systematic studies on crosslinking mechanisms in these systems.

Main Methods:

  • Focuses on physical crosslinking methods.
  • Details chemical crosslinking strategies.
  • Explores enzymatic crosslinking techniques.

Main Results:

  • Discusses various crosslinking mechanisms: hydrogen bonding, electrostatic, coordination, and self-assembly.
  • Highlights the formation of double, triple, and multiple networks.
  • Emphasizes the role of crosslinking in structural integrity and functionality.

Conclusions:

  • Systematic investigation of crosslinking in multicomponent hydrogels is needed.
  • Advanced crosslinking strategies are key to developing novel hydrogel-based biomedical materials.
  • This review provides insights into designing sophisticated hydrogel systems.