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Plasmablastic lymphomas show restricted EBV latency profile and MYC gene aberrations
Amsha Ramburan1,2, Raymond Kriel1, Dhirendra Govender1,3
1Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Leukemia & Lymphoma
|October 6, 2021
Summary
Plasmablastic lymphoma (PBL) pathogenesis involves Epstein-Barr virus (EBV) and MYC gene aberrations. This study found restricted EBV latency patterns and frequent MYC gene alterations in PBL patients, highlighting their common occurrence.
Area of Science:
- Oncology
- Virology
- Genetics
Background:
- Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma.
- Its pathogenesis is linked to Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), and MYC gene aberrations.
Purpose of the Study:
- To investigate the EBV latent infection patterns in PBL.
- To determine the frequency of MYC gene aberrations in PBL.
- To analyze these factors in a South African cohort.
Main Methods:
- Immunohistochemistry for EBV antigens (EBNA1, EBNA2, LMP1).
- Fluorescence in situ hybridization (FISH) for MYC gene alterations.
- Analysis of 49 adult PBL cases (44 HIV-positive, 3 HIV-negative).
Main Results:
- 41 out of 49 cases were EBV-positive.
- Predominant EBV latency patterns observed: Latency 0 (29 cases), Latency I (8 cases), Latency II (4 cases).
- MYC gene aberrations were common: 8 cases with rearrangement, 11 with copy number alterations.
Conclusions:
- PBL in this South African cohort exhibits a predominantly restricted EBV latency pattern.
- MYC gene aberrations are a frequent finding in PBL.
- These findings contribute to understanding PBL pathogenesis.
