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Cognition during active methamphetamine use versus remission.

Marilyn Huckans1,2,3,4, Stephen Boyd5, Grant Moncrief1,2,6,7

  • 1Research & Development Service, Veterans Affairs Portland Health Care System, Portland, OR, USA.

Journal of Clinical and Experimental Neuropsychology
|October 6, 2021
PubMed
Summary
This summary is machine-generated.

Cognitive performance in adults with active methamphetamine use (MA) did not differ from controls. However, those in remission from MA use showed memory deficits, highlighting potential recovery challenges.

Keywords:
Cognitionaddictiondependenceneuropsychologicalstimulantsubstance use disorder

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Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Medicine

Background:

  • Methamphetamine use disorder (MA) is a chronic relapsing condition.
  • Cognitive impairments are frequently observed in individuals with substance use disorders.
  • Understanding cognitive function during active use versus remission is crucial for effective treatment.

Purpose of the Study:

  • To compare cognitive performance between adults with active methamphetamine use (MA-ACT), adults in remission from methamphetamine use disorder (MA-REM), and controls (CTLs).

Main Methods:

  • Participants included three groups: MA-ACT (n=36), MA-REM (n=48), and CTLs (n=62).
  • Cognitive performance was assessed using the Neuropsychological Assessment Battery (NAB).

Main Results:

  • The MA-ACT group showed no significant cognitive deficits compared to CTLs across NAB Indices.
  • The MA-REM group performed significantly worse than CTLs on the NAB Memory Index (p < 0.050).
  • The MA-ACT group outperformed both CTLs and the MA-REM group on the Executive Functions Index.

Conclusions:

  • Cognitive deficits, particularly in memory, may emerge during remission from methamphetamine use.
  • These deficits during recovery could pose challenges for sustained treatment engagement and relapse prevention.
  • Cognitive function patterns differ between active methamphetamine use and its remission phase.