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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
Published on: June 27, 2022
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Hydrogen sulfide in ageing, longevity and disease
Stephen E Wilkie1, Gillian Borland1, Roderick N Carter2
1Glasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
The Biochemical Journal
|October 6, 2021
Summary
Hydrogen sulfide (H2S), once a toxic gas, is now known to promote longevity and health in aging. This review explores H2S
Area of Science:
- Biochemistry and Molecular Biology
- Gerontology
- Physiology
Background:
- Hydrogen sulfide (H2S) is an endogenously produced gas with significant biological roles.
- Initially perceived as toxic, H2S is now recognized for its involvement in longevity and healthspan.
- Its signaling functions are crucial across various taxa.
Purpose of the Study:
- To review the evolving understanding of H2S in aging and health.
- To discuss mechanisms by which H2S influences aging processes.
- To highlight novel H2S-based therapeutic strategies and associated challenges.
Main Methods:
- Literature review of scientific publications on H2S and aging.
- Analysis of current research on H2S signaling pathways.
- Evaluation of emerging H2S-based therapeutic approaches.
Main Results:
- H2S plays a key role in promoting longevity and improving health during aging.
- Mechanisms involve modulation of cellular processes central to aging.
- Novel therapeutic strategies utilizing H2S are emerging.
Conclusions:
- H2S is a critical endogenous mediator of healthy aging.
- Understanding H2S mechanisms can lead to new longevity therapeutics.
- Development of H2S therapies faces challenges that require further investigation.
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