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Related Concept Videos

Aging01:26

Aging

325
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
325
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Corrosion02:49

Corrosion

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The degradation of metals due to natural electrochemical processes is known as corrosion. Rust formation on iron, tarnishing of silver, and the blue-green patina that develops on copper are examples of corrosion. Corrosion involves the oxidation of metals. Sometimes it is protective, such as the oxidation of copper or aluminum, wherein a protective layer of metal oxide or its derivatives forms on the surface, protecting the underlying metal from further oxidation. In other cases, corrosion is...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Related Experiment Video

Updated: Oct 17, 2025

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
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Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

556

Iron: an underrated factor in aging.

Dennis Mangan1

  • 1MTOR LLC, Bakersfield, CA 93311, USA.

Aging
|October 6, 2021
PubMed
Summary

Iron is vital but harmful when accumulated, especially with aging. Lowering iron levels through various interventions may extend lifespan and improve healthspan.

Area of Science:

  • Biochemistry
  • Gerontology
  • Physiology

Background:

  • Iron is essential for life but its reactivity poses health risks.
  • Iron accumulation is linked to aging and age-related diseases, shortening lifespan in model organisms.
  • Existing lifespan interventions may act via iron metabolism modulation.

Purpose of the Study:

  • To explore the role of iron in aging and lifespan.
  • To investigate how modulating iron levels impacts healthspan and longevity.
  • To determine if controlling body iron is a viable anti-aging strategy.

Main Methods:

  • Review of existing literature on iron metabolism, aging, and lifespan interventions.
  • Analysis of the mechanisms underlying lifespan extension by rapamycin, calorie restriction, and plasma dilution in relation to iron.
Keywords:
agingcalorie restrictionironoxidative stressplasma dilution

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Last Updated: Oct 17, 2025

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
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  • Correlation of iron levels with age-related diseases and organismal lifespan.

    • Main Results:

    • Iron accumulation is a hallmark of aging and is associated with numerous age-related pathologies.
    • Interventions that extend lifespan, such as rapamycin and calorie restriction, affect iron homeostasis.
    • Reducing iron absorption or levels has been shown to prolong lifespan in model organisms.

    Conclusions:

    • Iron's dual role as essential nutrient and potential toxin is critical in aging.
    • Modulating iron absorption, excretion, and metabolism represents a promising therapeutic target for extending healthspan and lifespan.
    • Maintaining low-normal body iron stores could be a key intervention for healthy aging.