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Cerebral Perfusion in Pediatric Stroke: Children Are Not Little Adults
Sarah Lee1,2, Bin Jiang3, Jeremy J Heit3
1Department of Neurology and Neurological Sciences, Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA.
Insights
Cerebral perfusion imaging offers insights into brain hemodynamics for neurological conditions like stroke. This review covers magnetic resonance imaging techniques and their applications in adult and pediatric stroke and cerebrovascular disorders.
Area of Science:
- Neuroimaging
- Neurology
- Medical Imaging
Background:
- Cerebral perfusion imaging is crucial for understanding brain hemodynamics.
- It aids in diagnosing and managing neurological conditions such as stroke, epilepsy, and brain tumors.
- Various imaging techniques utilize tracers to measure cerebral blood volume and flow.
Purpose of the Study:
- To provide an overview of magnetic resonance imaging (MRI) perfusion techniques.
- To summarize the role of perfusion imaging in adult stroke.
- To discuss pediatric cerebrovascular disorders and stroke, including changes in cerebral blood flow over childhood.
Main Methods:
- Review of magnetic resonance imaging perfusion techniques.
- Analysis of existing literature on perfusion imaging in stroke and cerebrovascular disorders.
- Description of cerebral blood flow changes throughout childhood.
Main Results:
- Perfusion imaging provides valuable hemodynamic information relevant to neurological conditions.
- MRI perfusion techniques are established tools for evaluating brain blood flow.
- Understanding perfusion changes is key for diagnosing and managing stroke and cerebrovascular issues.
Conclusions:
- Cerebral perfusion imaging, particularly MRI, is essential for evaluating brain hemodynamics in various neurological conditions.
- Its application in adult stroke is summarized, with a focus on pediatric cerebrovascular disorders and stroke.
- Future directions in pediatric perfusion imaging hold significant potential for improved diagnostics and treatment.
Abstract:
Cerebral perfusion imaging provides useful information about the hemodynamic state of the brain that is relevant to a number of neurologic conditions, including stroke, epilepsy, and brain tumors. Multiple imaging modalities have been developed to evaluate brain perfusion, primarily by the use of different tracers to measure cerebral blood volume and cerebral blood flow. Here, we provide an overview of magnetic resonance imaging perfusion techniques; summarize the role of perfusion imaging in adult stroke; describe changes in cerebral blood flow over childhood; and discuss the relevance and future directions of perfusion imaging in pediatric cerebrovascular disorders and stroke.
