Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Operon Model01:23

Operon Model

398
The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...
398
Structural Protein Function01:56

Structural Protein Function

2.9K
2.9K
Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

204
Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
204
Keystone Species01:39

Keystone Species

22.6K
Measures of species biodiversity, such as richness (i.e., the number of species present) and evenness (i.e., their relative abundance), describe an ecological community’s structure. Many factors affect community structure, including abiotic factors (e.g., sunlight and nutrients), disturbances (e.g., fire or flood), species interactions (e.g., predation or competition), and chance events (e.g., foreign species invasion). Certain species—such as keystone species—also play a...
22.6K
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

22.2K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
22.2K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

4.9K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

Communications chemistry·2026
Same author

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Journal of medicinal chemistry·2026
Same author

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Nature chemical biology·2026
Same author

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.

ACS medicinal chemistry letters·2026
Same author

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

bioRxiv : the preprint server for biology·2026
Same author

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry.

The EMBO journal·2026

Related Experiment Video

Updated: Oct 17, 2025

gP2S, an Information Management System for CryoEM Experiments
13:01

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

5.6K

The structural and functional workings of KEOPS.

Jonah Beenstock1, Frank Sicheri1,2,3

  • 1The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.

Nucleic Acids Research
|October 6, 2021
PubMed
Summary

The Kinase, Endopeptidase and Other Proteins of Small size (KEOPS) complex is vital for cell health and animal development. Research is advancing our understanding of KEOPS

More Related Videos

Specimen Preparation, Imaging, and Analysis Protocols for Knife-edge Scanning Microscopy
10:25

Specimen Preparation, Imaging, and Analysis Protocols for Knife-edge Scanning Microscopy

Published on: December 9, 2011

17.9K
The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders
10:08

The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders

Published on: August 25, 2022

3.1K

Related Experiment Videos

Last Updated: Oct 17, 2025

gP2S, an Information Management System for CryoEM Experiments
13:01

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

5.6K
Specimen Preparation, Imaging, and Analysis Protocols for Knife-edge Scanning Microscopy
10:25

Specimen Preparation, Imaging, and Analysis Protocols for Knife-edge Scanning Microscopy

Published on: December 9, 2011

17.9K
The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders
10:08

The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders

Published on: August 25, 2022

3.1K

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • The KEOPS complex is a highly conserved eukaryotic and archaeal machinery essential for cellular fitness and animal development.
  • Mutations in KEOPS genes are linked to Galloway-Mowat syndrome, a severe human developmental disorder.
  • The Kae1 subunit catalyzes the crucial tRNA modification N6-threonylcarbamoyl adenosine (t6A), with auxiliary subunits supporting its function.

Purpose of the Study:

  • To review recent advancements in KEOPS research.
  • To highlight the functional roles of KEOPS subunits.
  • To identify future research directions in the KEOPS field.

Main Methods:

  • Literature review of KEOPS research over the past 15 years.
  • Analysis of the structural and functional roles of KEOPS subunits.
  • Synthesis of findings related to KEOPS in cellular processes and human disease.

Main Results:

  • KEOPS is essential for tRNA modification (t6A) and cellular viability.
  • KEOPS plays a critical role in animal development.
  • Dysfunctional KEOPS leads to severe human genetic disorders like Galloway-Mowat syndrome.

Conclusions:

  • Significant progress has been made in understanding KEOPS function and its link to human disease.
  • Further research is needed to fully elucidate KEOPS mechanisms and therapeutic potential.
  • Future studies will focus on KEOPS' role in various biological contexts and disease pathologies.