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Updated: Oct 17, 2025

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation
Ching-In Lau1, Diana C Yánez1,2, Eleftheria Papaioannou1,3
1UCL Great Ormond Street Institute of Child Health, London, UK.
Abstract:
Epithelial barrier tissues such as the skin and airway form an essential interface between the mammalian host and its external environment. These physical barriers are crucial to prevent damage and disease from environmental insults and allergens. Failure to maintain barrier function against such risks can lead to severe inflammatory disorders, including atopic dermatitis and asthma. Here, we discuss the role of the morphogen Sonic Hedgehog in postnatal skin and lung and the impact of Shh signalling on repair, inflammation, and atopic disease in these tissues.
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