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Outcomes of Patients with COPD Hospitalized for Coronavirus Disease 2019

Daniel A Puebla Neira1, Abigail Watts1, Justin Seashore1

  • 1Division of Pulmonary, Critical Care and Sleep Medicine Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States.

Chronic Obstructive Pulmonary Diseases (Miami, Fla.)
|October 6, 2021
PubMed

Insights

Chronic obstructive pulmonary disease (COPD) increases mortality risk for hospitalized COVID-19 patients. This risk is particularly significant for females and individuals aged 40-79.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Controversy exists regarding chronic obstructive pulmonary disease (COPD) as an independent risk factor for mortality in Coronavirus Disease 2019 (COVID-19) hospitalized patients.
  • This study investigated the hypothesis that COPD exacerbates mortality risk in COVID-19 inpatients.

Purpose of the Study:

  • To determine if COPD independently elevates mortality risk among individuals hospitalized with COVID-19.
  • To analyze the interaction of COPD with demographic factors like sex and age in COVID-19 mortality.

Main Methods:

  • Retrospective cohort analysis of 31,526 patients diagnosed with COVID-19 between February 10, 2020, and November 10, 2020.
  • Utilized electronic health records from U.S. facilities (Optum COVID-19 data) for hospitalized patients within 14 days of diagnosis.
  • Employed univariate and multivariate analyses to assess mortality odds ratios and confidence intervals.

Main Results:

  • Overall mortality was 9.6% (3030 deaths).
  • COPD patients exhibited higher mortality (14.02%) compared to non-COPD patients (8.8%).
  • Multivariate analysis confirmed COPD as a significant risk factor (OR 1.33; 95% CI 1.18 to 1.50).
  • Increased mortality risk associated with COPD was significant in females and patients aged 40-79, but not in males.

Conclusions:

  • Chronic obstructive pulmonary disease is identified as an independent risk factor for mortality in adults aged 40-79 hospitalized with COVID-19.
  • The findings highlight the critical impact of COPD on COVID-19 outcomes within specific demographic groups.
Abstract

Keywords:
COVID-19Chronic ObstructiveMortalityPulmonary Disease

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