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Updated: Oct 17, 2025

Digital Inline Holographic Microscopy DIHM of Weakly-scattering Subjects
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Dynamic coherent diffractive imaging with a physics-driven untrained learning method.

Dongyu Yang, Junhao Zhang, Ye Tao

    Optics Express
    |October 7, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Deep CDI, a novel physics-driven untrained learning method, reconstructs complex objects from single diffraction patterns. This approach enables high-confidence, fast imaging of dynamic processes without extensive training data.

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    Area of Science:

    • Computational imaging
    • Coherent diffraction imaging (CDI)

    Background:

    • Reconstructing complex fields from single diffraction measurements is challenging.
    • Conventional iterative algorithms are slow and struggle with convergence.
    • Deep learning methods require large, often unobtainable, training datasets.

    Purpose of the Study:

    • To introduce a physics-driven, untrained learning method for complex field reconstruction.
    • To enable high-confidence and fast imaging of dynamic processes using CDI.
    • To overcome limitations of conventional and deep learning approaches in CDI.

    Main Methods:

    • Developed Deep CDI, combining a neural network with a physical imaging model.
    • Utilized support region and free propagation constraints for loss calculation.
    • Optimized network weights by summing losses from both constraints.

    Main Results:

    • Demonstrated feasibility through numerical simulations and optical experiments on static samples.
    • Successfully imaged a dynamic process using 3600 diffraction patterns.
    • Achieved an average reconstruction speed of 228 frames per second.

    Conclusions:

    • Deep CDI offers a viable solution for complex field reconstruction from single diffraction patterns.
    • The method effectively images dynamic processes with high speed and confidence.
    • Physics-driven untrained learning provides an alternative to data-intensive deep learning methods in CDI.