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Related Experiment Video

Updated: Oct 17, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

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Simultaneous directional full-field OCT using path-length and carrier multiplexing.

Denise Valente, Kari V Vienola, Robert J Zawadzki

|October 7, 2021

Summary

This summary is machine-generated.

This study introduces carrier modulation (CM) to multiplex signals in full-field swept-source optical coherence tomography (FF-SS-OCT). This novel method enables simultaneous measurement of differential scattering anisotropy in 2D for advanced imaging applications.

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

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Published on: August 4, 2018

Area of Science:

Optical Engineering
Biomedical Imaging
Metrology

Background:

Full-field swept-source optical coherence tomography (FF-SS-OCT) is an advanced imaging technique.
Existing FF-SS-OCT methods have limitations in analyzing scattered light properties.

Purpose of the Study:

To demonstrate a novel carrier modulation (CM) method for multiplexing FF-SS-OCT signals.
To utilize CM for measuring differential scattering anisotropy in two dimensions simultaneously.

Main Methods:

Developed a carrier multiplexed directional FF-OCT (CM-D-FF-OCT) system.
Employed carrier modulation to acquire images through two distinct optical pupils with perpendicular semicircular windows.
Induced optical delays to measure scattering anisotropy in orthogonal dimensions.

Main Results:

Successfully demonstrated the CM technique for multiplexing FF-SS-OCT signals.
Acquired images of a microlens array, human hair, onion skin, and in vivo human retina.
Achieved simultaneous measurement of differential scattering anisotropy in both x and y dimensions.

Conclusions:

Carrier modulation is a feasible technique for enhancing FF-SS-OCT capabilities.
The CM-D-FF-OCT system shows potential for advanced material and biological tissue analysis.
Future applications include detailed inspection of scattering properties in various domains.