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SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis

Felicia Hartmann1, Daniel J Gorski1, Alexandra A C Newman2,3,4

  • 1Institute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany (F.H., D.J.G., S.H., A.P., J.W.F.).

Circulation Research
|October 7, 2021
PubMed

Keywords:
atherosclerosisextracellular matrixgalectin-3micephenotype

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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