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Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.3K

Pediatric choroidal neovascularization: Etiology and treatment outcomes with anti-vascular endothelial growth factors

Ratnesh Ranjan1, Romit Salian1, Shishir Verghese1

  • 1Department of Retina and Vitreous services, Aravind Eye Hospital, Coimbatore, India.

European Journal of Ophthalmology
|October 7, 2021
PubMed

Insights

Intravitreal anti-vascular endothelial growth factor (VEGF) injections effectively treat choroidal neovascularization (CNV) in children. This therapy led to significant visual acuity improvement and reduced macular thickness in pediatric patients.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Pediatric Medicine

Background:

  • Choroidal neovascularization (CNV) can impact vision in pediatric patients.
  • Treatment options for pediatric CNV require evaluation for efficacy and safety.

Purpose of the Study:

  • To determine the etiology and treatment outcomes of pediatric choroidal neovascularization (CNV).
  • To assess the effectiveness of intravitreal anti-vascular endothelial growth factor (VEGF) agents in treating pediatric CNV.

Main Methods:

  • Retrospective, single-center interventional case series.
  • Treatment involved intravitreal injections of anti-VEGF agents in 26 eyes of 23 pediatric patients.
  • Data collected included etiology, visual acuity, and macular thickness.

Main Results:

  • Inflammatory CNV was the most common cause in the pediatric cohort.
  • Intravitreal anti-VEGF therapy resulted in significant improvement in best-corrected visual acuity (BCVA) (logMAR 0.8 to 0.4, p < 0.0001).
  • Mean central macular thickness (CMT) significantly decreased (367.6 µm to 242.5 µm, p < 0.0001) with a mean of two injections per eye.

Conclusions:

  • Intravitreal anti-VEGF therapy is an effective treatment for pediatric choroidal neovascularization.
  • The treatment demonstrated positive outcomes in visual acuity and macular structure in children.
Abstract

Keywords:
CNVChoroidal neovascularizationanti-VEGFanti-vascular endothelial growth factorpediatric choroidal neovascularization

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