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Secondary analysis of malaria rapid diagnostic tests from rounds 5-8 of WHO product testing with a focus on
1Chinese Military Medical Expert Group in Sierra Leone, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.
Abstract:
Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5-8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density, improper RDT storage, operation and interpretation, and plasmodium falciparum with a pfhrp2/3 gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.
