IgG4-related Disease with a Cardiac Mass Causing Cerebral Infarction

Area of Science:

• Cardiology
• Rheumatology
• Pathology

Background:

• Immunoglobulin G4-related disease (IgG4-RD) is a multisystem fibroinflammatory condition.
• While IgG4-RD can affect nearly any organ, myocardial involvement is exceptionally rare.

Observation:

• A patient presented with a cardiac mass in the right atrium, involving the sinus node.
• This mass led to significant clinical manifestations including arrhythmia and recurrent strokes.

Findings:

• The cardiac mass was diagnosed as IgG4-related disease.
• Successful management involved surgical resection of the mass, catheter ablation for arrhythmia, and immunosuppressive therapy.

Implications:

• This case highlights the importance of considering IgG4-RD in cardiac masses, even in rare presentations.
• Multidisciplinary treatment approaches can effectively manage cardiac IgG4-RD, improving patient outcomes and preventing further complications like stroke.