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One-pot three-component tandem annulation of 4-hydroxycoumarine with aldehyde and aromatic amines using graphene
Rabindranath Singha1, Aminul Islam1, Pranab Ghosh2
1Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India.
Abstract:
A convenient and efficient solvent-free, facile, one-pot three-component graphene oxide catalysed approach has been described for the synthesis of chromeno-[4,3-b]quinolin-6-one derivatives from 4-hydroxycoumarin with aldehydes and aromatic amines. Graphene oxide (GO) has proved to be a new class of heterogeneous carbocatalyst which could be easily recovered and reused up to 5th run without significant loss of its catalytic activity. A broad scope of substrate applicability is offered and a plausible mechanism is also suggested for this developed protocol.
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