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Motor and Sensory Areas of the Cortex

Motor and Sensory Areas of the Cortex

The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....

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The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.

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Related Experiment Video

Updated: Oct 17, 2025

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Isoform cell-type specificity in the mouse primary motor cortex.

A Sina Booeshaghi¹, Zizhen Yao², Cindy van Velthoven²

¹Department of Mechanical Engineering, California Institute of Technology, Pasadena, CA, USA.

|October 7, 2021

Summary

This summary is machine-generated.

Single-cell RNA sequencing reveals cell-type-specific gene isoforms, offering a more refined understanding of cellular identity and transcriptional regulation in the mouse brain. This multi-platform approach enhances cell type resolution beyond gene-level analysis.

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Rapid and Specific Immunomagnetic Isolation of Mouse Primary Oligodendrocytes

Rapid and Specific Immunomagnetic Isolation of Mouse Primary Oligodendrocytes

Published on: May 21, 2018

Area of Science:

Transcriptomics
Neuroscience
Genomics

Background:

Single-cell RNA sequencing (scRNA-seq) provides insights into cellular heterogeneity.
Gene expression analysis at the isoform level offers higher resolution than traditional gene-level studies.
Understanding cell-type-specific transcription is crucial for neuroscience research.

Purpose of the Study:

To investigate cell-type-specific gene isoform expression in the mouse primary motor cortex.
To determine if isoform-level analysis refines cell type classification and reveals transcriptional regulation.
To assess the benefits of a multi-platform scRNA-seq approach for creating a comprehensive transcriptomic atlas.

Main Methods:

Comprehensive analysis of 6,160 mouse primary motor cortex cells using full-length SMART-seq.
Integration of data from MERFISH (280,327 cells) and 10x Genomics (94,162 cells) sequencing platforms.
Application of spatial RNA capture and gene-tagging methods for spatially resolved isoform expression inference.

Main Results:

Identified cell-type-specific gene isoforms, including shifts masked in gene-level analysis.
Observed examples of transcriptional regulation at the isoform level.
Demonstrated that isoform specificity enhances cell type refinement and improves transcriptomic atlas resolution.

Conclusions:

Isoform resolution in scRNA-seq is critical for accurate cell type identification and understanding transcriptional regulation.
A multi-platform approach integrating various scRNA-seq technologies provides a more comprehensive mouse primary motor cortex transcriptomic atlas.
Isoform-level analysis significantly improves upon single-technology capabilities for detailed cellular characterization.