Related Experiment Video
Updated: Oct 17, 2025
07:12
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
2.5K
Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis
Ine Suharyani1,2, Ahmed Fouad Abdelwahab Mohammed3, Muchtaridi Muchtaridi4
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Sumedang, Jatinangor, 45363, Indonesia.
Drug Design, Development and Therapy
|October 7, 2021
Summary
Recurrent aphthous stomatitis (RAS) treatments utilize drug delivery systems (DDS) to improve oral ulcer healing and pain relief. Semi-solid formulations, particularly those using mucoadhesive polymers, show promise for extended residence time and enhanced efficacy.
Area of Science:
- Oral medicine and drug delivery systems
- Pharmaceutical sciences and formulation development
Background:
- Recurrent aphthous stomatitis (RAS) presents as painful oral lesions, necessitating effective topical treatments.
- Oral drug delivery systems (DDS) face challenges like rapid saliva wash-out, reducing drug residence time and efficacy.
- Managing RAS requires DDS that enhance wound healing, ulcer coverage, and pain relief directly on oral mucosa.
Purpose of the Study:
- To review the evolution of preparation forms and delivery systems for Recurrent Aphthous Stomatitis (RAS) management.
- To analyze various drug delivery systems (DDS) developed for RAS treatment from 1965 to February 2020.
Main Methods:
- A comprehensive literature review of 62 articles focusing on DDS for RAS.
- Classification of 20 identified DDS types into four preparation forms: liquid, semi-solid, solid, and miscellaneous.
- Analysis of formulation strategies, including the use of mucoadhesive polymers.
Main Results:
- Semi-solid formulations (gels, pastes, patches, creams, ointments) represent the most common DDS for RAS (41.94%).
- Novel preparation forms, including adhesive alginates and gelosomes, have emerged, accounting for 11.29% of DDS.
- Topical DDS utilizing mucoadhesive polymers are prevalent for increasing residence time and providing pain relief.
Conclusions:
- Drug delivery systems are crucial for improving drug delivery and activity in treating RAS ulcers.
- Semi-solid and novel mucoadhesive formulations offer enhanced therapeutic potential for oral mucosal conditions like RAS.
- Optimizing DDS for oral mucosa targets increased drug residence time and effective pain management in RAS patients.
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
541
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
541
01:16Drug Delivery: Overview
477
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
477
01:18Drug Delivery: Enteral Route
871
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
871
01:15Non-Oral Extravascular Drug Absorption Routes
333
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
333
01:18Routes of Drug Administration: Enteral
5.0K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
5.0K
01:27Bioavailability Enhancement: Drug Permeability Enhancement
20
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
20