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Gene polymorphism of 3'APO-VNTR in Egyptians with coronary artery disease

Rehab Elmougy1

  • 1Mansoura University, Faculty of Science, Chemistry Department, Division of Biochemistry, Mansoura, Egypt.

Journal of Medical Biochemistry
|October 7, 2021
PubMed

Insights

The 3'APOB-VNTR gene may be a risk factor for coronary artery diseases (CAD). This genetic marker could aid in the early diagnosis of CAD, a leading global cause of death.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Coronary artery diseases (CAD) represent a significant global health burden and a leading cause of mortality worldwide.
  • Dyslipidemia is a known risk factor that elevates the likelihood of developing CAD.
  • Investigating genetic factors like the 3'APOB-VNTR gene is crucial for understanding CAD etiology.

Purpose of the Study:

  • To investigate the potential impact of the 3'APOB-VNTR gene polymorphism on the incidence of coronary artery diseases (CAD).
  • To explore the association between specific 3'APOB-VNTR genotypes and the presence of CAD.

Main Methods:

  • The study enrolled 80 patients diagnosed with CAD and 93 healthy control volunteers.
  • Lipid parameters were measured in all participants.
  • Polymerase Chain Reaction (PCR) was employed to analyze the 3'APOB-VNTR gene polymorphism.

Main Results:

  • Specific genotypes (31/31, 31/37, 37/37, 31/44) were prevalent in both CAD patients and controls.
  • The 24/31 genotype was observed in 13.7% of CAD patients but was absent in the control group.
  • An increased frequency of certain genotypes (e.g., 17/31, 21/34) was noted in the control group compared to the CAD patient group.

Conclusions:

  • The 3'APOB-VNTR gene is suggested as a potential risk factor for coronary artery diseases (CAD).
  • Analysis of this gene polymorphism may contribute to the early diagnosis of CAD.
Abstract

Keywords:
Apo BPCRcoronary artery diseasedyslipidemiagenetics

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