Recurrent Dysphagia Associated with Esophageal Intramural Pseudodiverticulosis
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Updated: Oct 17, 2025

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Published on: August 11, 2023
Haider Naqvi1,2,3,4, Muhammad Nadeem Yousaf1,2,3,4, Gavneet Sandhu1,2,3,4
1Department of Medicine, Medstar Union Memorial Hospital, Baltimore, Maryland, USA.
Abstract:
Esophageal intramural pseudodiverticulosis (EIPD) is a rare disorder of the esophagus characterized by the presence of outpouching flask-shaped lesions. These lesions represent false lumens that may be scattered throughout the esophageal wall. We present a rare case of EIPD complicated with esophageal strictures. The case is unique because the small lesions of EIPD remained undiagnosed for many years on prior esophagogastroduodenoscopy examinations until complicated with worsening symptoms of dysphagia due to esophageal stricture. The patient was managed with serial dilations of esophageal stricture. Diagnosing these lesions may be missed in early stages as the lesions are small and may require other radiological modalities to confirm the diagnosis. EIPD lesions itself can be managed conservatively with anti-inflammatory therapy and treatment of underlying risk factors. Those with severe disease and coexisting complications are managed with endoscopic or surgical interventions.
Insights
Esophageal intramural pseudodiverticulosis (EIPD) is a rare esophageal condition. This case highlights delayed diagnosis of EIPD, leading to esophageal strictures managed with dilations.
Area of Science:
- Gastroenterology
- Esophageal Diseases
- Rare Medical Conditions
Background:
- Esophageal intramural pseudodiverticulosis (EIPD) is a rare condition characterized by flask-shaped outpouchings in the esophageal wall.
- These pseudodiverticula represent false lumens and can be challenging to diagnose in early stages.
Observation:
- A rare case of EIPD is presented, complicated by the development of esophageal strictures.
- The EIPD lesions were initially missed during multiple esophagogastroduodenoscopy examinations.
- The patient experienced worsening dysphagia due to the esophageal stricture, necessitating intervention.
Findings:
- The study highlights the diagnostic challenges of EIPD, particularly when lesions are small and asymptomatic.
- Advanced imaging modalities may be required for definitive diagnosis when endoscopy is inconclusive.
- The patient's esophageal stricture, a complication of EIPD, was successfully managed with serial dilations.
Implications:
- This case underscores the importance of considering EIPD in patients with unexplained esophageal symptoms, even with prior negative endoscopies.
- Early diagnosis and management of EIPD can prevent complications like esophageal strictures.
- Treatment strategies for EIPD range from conservative medical management to endoscopic or surgical interventions for severe cases or complications.
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