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Updated: Oct 17, 2025
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
MicroRNA expression in inflammatory bowel disease-associated colorectal cancer
Thais Gagno Grillo1, Ana Elisa Valencise Quaglio2, Rodrigo Fedatto Beraldo1
1Department of Internal Medicine, São Paulo State University (Unesp), Medical School, Botucatu 18618-686, São Paulo, Brazil.
MicroRNAs (miRNAs) are key regulators in immune disorders like inflammatory bowel diseases (IBD). This review highlights miRNAs as potential biomarkers for diagnosing and predicting colorectal cancer (CRC) risk in IBD patients.
Area of Science:
- Molecular Biology
- Oncology
- Gastroenterology
Background:
- MicroRNAs (miRNAs) regulate gene expression and are implicated in immune-mediated disorders.
- Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, involve chronic intestinal inflammation.
- IBD patients have an increased risk of colorectal cancer (CRC), a prevalent malignancy.
Purpose of the Study:
- To review the role of miRNAs as biomarkers for IBD-associated colorectal cancer (CRC).
- To explore the diagnostic and prognostic potential of miRNAs in IBD patients at risk for CRC.
Main Methods:
- Literature review of recent studies on miRNAs and IBD-associated CRC.
- Analysis of identified miRNAs linked to increased CRC risk in IBD populations.
Main Results:
- Recent studies have identified specific miRNAs associated with elevated CRC risk in IBD patients.
- These miRNAs could aid in stratifying cancer risk, monitoring, and assessing prognosis for IBD patients.
Conclusions:
- miRNAs show promise as biomarkers for the diagnosis and prognosis of IBD-associated CRC.
- Future miRNA-based therapies could manage IBD and identify high-risk individuals for CRC development.
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