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Label-free Single Molecule Detection Using Microtoroid Optical Resonators
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Cellular and biomolecular detection based on suspended microchannel resonators.
Juhee Ko1, Jaewoo Jeong1, Sukbom Son1
1Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daehak-ro 291, Daejeon, South Korea.
Biomedical Engineering Letters
|October 7, 2021
Summary
Suspended microchannel resonators (SMRs) precisely measure single particle and cell buoyant mass in liquid. These advanced resonators offer high mass resolution and throughput for biological and biomedical research.
Area of Science:
- Biotechnology
- Nanotechnology
- Biomedical Engineering
Background:
- Suspended microchannel resonators (SMRs) are advanced tools for measuring the buoyant mass of micro-/nanoparticles and cells in liquid.
- SMRs offer significant improvements in mass resolution through vacuum packaging and increased measurement throughput via fast resonance frequency tracking.
Purpose of the Study:
- To provide a comprehensive review of the development, operation, and applications of SMRs.
- To introduce SMR technology to researchers in biological and biomedical sciences.
- To highlight future perspectives and projections for SMR technologies.
Main Methods:
- Review of historical development and technological advancements in SMRs.
- Detailed explanation of basic and advanced SMR operational principles.
- Compilation and analysis of key biological and biomedical applications of SMRs.
Main Results:
- SMRs enable precise buoyant mass measurements of individual micro-/nanoparticles and cells.
- Vacuum packaging enhances mass resolution, while fast frequency tracking boosts throughput.
- SMRs have facilitated applications such as cell growth monitoring and disease-associated physicochemical change analysis.
Conclusions:
- SMRs represent a powerful technology for high-resolution, high-throughput mass measurements in liquid.
- The technology has broad applicability in biological and biomedical research, complementing conventional methods.
- Ongoing advancements promise expanded functionalities and new application frontiers for SMRs.
