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Updated: Oct 17, 2025
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Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction
Published on: June 1, 2022
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Exhaled volatile organic compounds and lung microbiome in COPD: a pilot randomised controlled trial
Divya Mohan1, Holly R Keir2, Hollian Richardson2
1GSK R&D, Collegeville, PA, USA.
ERJ Open Research
|October 7, 2021
Summary
Volatile organic compounds (VOCs) in breath are feasible to measure in clinical trials for COPD patients. Gas chromatography-mass spectrometry (GC-MS) showed a link between specific VOCs and Haemophilus bacteria.
Area of Science:
- Pulmonary Medicine
- Analytical Chemistry
- Microbiology
Background:
- Breath analysis using volatile organic compounds (VOCs) is a promising noninvasive diagnostic tool.
- No randomized controlled trials (RCTs) have longitudinally evaluated VOC measurement in clinical settings.
- Investigating VOCs in Chronic Obstructive Pulmonary Disease (COPD) can offer new insights.
Purpose of the Study:
- To assess the feasibility of measuring VOCs via multiple techniques in a pilot RCT.
- To explore the relationship between VOCs and Haemophilus colonization in COPD patients.
- To determine if danirixin affects lung microbiome composition.
Main Methods:
- 43 participants with COPD underwent VOC and sputum biomarker analysis.
- VOCs and sputum were collected at screening and days 1, 7, and 14.
- VOCs were analyzed using gas chromatography-mass spectrometry (GC-MS), FAIMS, and eNose.
Main Results:
- A modest relationship (R²=0.55) was found between four exhaled VOCs and Haemophilus abundance using GC-MS.
- FAIMS and eNose did not show a significant relationship between VOCs and Haemophilus.
- Significant longitudinal variability in individual VOC quantities was observed.
Conclusions:
- VOC measurement is feasible in clinical trials for COPD patient stratification.
- New VOC technologies require concurrent GC-MS validation.
- Standardized VOC collection and "housekeeper" VOC measurement are needed for normalization.
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