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Circulating microRNA in patients with popliteal and multiple artery aneurysms
Dick Wågsäter1, Hans Ravn2,3, Anders Wanhainen2,4
1Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Jvs-Vascular Science
|October 7, 2021
Summary
Specific microRNAs (miRs) in blood correlate with the number and location of popliteal artery aneurysms (PA), including abdominal aortic aneurysms (AAA). These findings may help identify biomarkers for different PA patient subgroups.
Area of Science:
- Vascular Biology
- Molecular Diagnostics
- Biomarker Discovery
Background:
- Popliteal artery aneurysm (PA) frequently co-occurs with other aneurysms like abdominal aortic aneurysm (AAA) or bilateral PA.
- MicroRNAs (miRs) are key biological regulators and are being explored as potential biomarkers for aneurysmal diseases.
Purpose of the Study:
- To investigate the correlation between the presence and location of multiple aneurysms and circulating miR levels in patients with PA.
- To identify potential miR biomarkers specific to different PA patient subgroups.
Main Methods:
- Quantitative polymerase chain reaction (qPCR) was used to analyze 23 miRs in plasma samples.
- The study included 183 patients diagnosed with popliteal artery aneurysm.
Main Results:
- Fifteen miRs showed significant associations with aneurysm number and/or location, with fold changes ranging from 1.3 to 2.1.
- miR-93 and miR-215 levels were altered across all compared groups.
- Specific miRs (e.g., miR-24, miR-23a, miR-145, miR-326) were differentially expressed in patients with AAA, bilateral PA, or isolated PA.
Conclusions:
- Distinct miRs may serve as important biomarkers for specific subgroups of PA patients.
- The identified miRs are involved in pathways regulating vascular smooth muscle cell proliferation and inflammation.
- Further research is necessary to elucidate the role of these miRs in the pathogenesis of aneurysmal disease.
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